A prospective study of reproductive factors and risk of epithelial ovarian cancer.
Parity and long term use of oral contraceptives have been associated consistently with a decreased risk of ovarian cancer.
However, previous reports of the relationship of other reproductive factors (time since first use or last use of oral contraceptives, age at menarche or menopause, age at first birth) with ovarian cancer have been inconsistent.
The authors studied these relationships in the Nurses'Health Study, a prospective cohort study of 121,700 female registered nurses aged 30-55 years in 1976 when the study began.
From 1976 to 1988,260 cases of confirmed epithelial ovarian cancer occurred among 1.2 million person-years of follow-up.
A statistically significant inverse association was observed between parity and ovarian cancer risk ; age at first birth was not associated independently with risk.
In age-adjusted analyses, a significant inverse association was noted between long term use of oral contraceptives and ovarian cancer, which was no longer significant after controlling for other ovarian cancer risk factors.
In this large prospective study, parity was the only reproductive factor that had a substantial independent association with ovarian cancer.
Long term oral contraceptive use also appeared to have an inverse relationship with ovarian cancer, although this association was of borderline significance (P=0.11) after adjustment for other risk factors.
Mots-clés Pascal : Epithélioma, Ovaire, Homme, Facteur risque, Epidémiologie, Parité, Contraception, Voie orale, Puberté, Ménopause, Age, Etude cohorte, Gestation, Appareil génital femelle pathologie, Ovaire pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Ovary, Human, Risk factor, Epidemiology, Parity, Contraception, Oral administration, Puberty, Menopause, Age, Cohort study, Pregnancy, Female genital diseases, Ovarian diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0508166
Code Inist : 002B20C02. Création : 01/03/1996.