The hepatitis E virus is responsible for epidemic and sporadic hepatitis in northwestern China, but its role as a cause of acute sporadic hepatitis in southern China has not been reported.
We applied the most practical current methods for diagnosis of hepatitis E virus infection, IgM and IgG anti-HEV detection by enzyme linked immunosorbent assay, to investigate the prevalence of hepatitis E virus infection among acute sporadic hepatitis.
Anti-HEV IgM was found in 1 of 26 (3.8%), 4 of 20 (20.0%), 4 of 19 (21.1%), and 51 of 142 (35.9%), with acute hepatitis A, B, C and non-ABC, respectively.
Anti-HEV IgM was not detectable in healthy subjects, while IgG anti-HEV was found in 14 of 77 healthy subjects (18.2%) and was long-lasting.
Ninety-one cases without any evidence of hepatitis A, B or C infections and anti-HEV IgM were tentatively classified as non-A, B, C, D, E (non-ABCDE) hepatitis.
Hepatitis E virus infection is sporadic as well as endemic in southern China.
Only IgM anti-HEV but not IgG anti-HEV can be used as an appropriate marker of acute hepatitis E virus infection.
Superinfection of hepatitis E virus with other types of hepatitis viruses is frequent in this area.
While the disease was associated with more severe clinical manifestations, patients usually recovered completely.
Mots-clés Pascal : Infection, Virus hépatite E, Virus, Aigu, Sporadique, Exploration immunologique, Epidémiologie, Homme, Chine, Asie, Foie pathologie, Appareil digestif pathologie, Virose
Mots-clés Pascal anglais : Infection, Hepatitis E virus, Virus, Acute, Sporadic, Immunological investigation, Epidemiology, Human, China, Asia, Hepatic disease, Digestive diseases, Viral disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0503241
Code Inist : 002B05C02G. Création : 01/03/1996.