To examine the relation between serum fatty acids and coronary heart disease (CHD), the authors conducted a nested case-control study of 94 men with incident CHD and 94 men without incident CHD who were enrolled in the Usual Care group of the Multiple Risk Factor Intervention Trial between December 1973 and February 1976.
After confirming the stability of the stored serum samples, the authors measured serum fatty acid levels by gas-liquid chromatography and examined their association with CHD.
In all multivariate models, levels of the cholesterol ester saturated fatty acid palmitic acid (16 : 0) were directly associated with CHD risk (standardized odds ratio=1.68 ; 95% confidence interval 1.10-2.55 in the model that adjusted for total plasma cholesterol level).
Levels of the phospholipid omega-3 fatty acid docosapentaenoic acid (22 : 5) were inversely associated with CHD risk in the two multivariate models that controlled for the effects of total plasma cholesterol level or high density lipoprotein cholesterol to total plasma cholesterol ratio.
These findings are consistent with other evidence indicating that saturated fatty acids are directly correlated with CHD and that omega-3 polyunsaturated fatty acids are inversely correlated with CHD.
Because these associations were present after adjustment for blood lipid levels, other mechanisms, such as a direct effect on blood clotting, may be involved.
Am J Epidemiol 1995 ; 142 : 469-76.
Mots-clés Pascal : Cardiopathie coronaire, Epidémiologie, Homme, Sérum, Taux, Acide gras polyinsaturé, Acide gras saturé, Régime alimentaire, Alimentation, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Lipide
Mots-clés Pascal anglais : Coronary heart disease, Epidemiology, Human, Serum, Rate, Polyunsaturated fatty acid, Saturated fatty acid, Diet, Feeding, United States, North America, America, Cardiovascular disease, Lipids
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0502957
Code Inist : 002B12A03. Création : 01/03/1996.