Assumptions and contradictions in measles and measles immunization research : is measles good for something ?
Global immunization and culture : compliance and resistance in large-scale public health campaigns. Symposium. .
Abstraclt-Measles infection, the major cause of childhood mortality among infections preventable by immunization, has been considered to kill mainly young and malnourished children.
Assuming that mainly'weak'children are saved by immunizations, it has been speculated that the impact on survival of immunization is likely to be limited because the malnourished children are more prone to die of other infections.
However, recent studies from developing countries have suggested that host factors may not be the most important determinants of acute and long-term mortality after measles infection.
Instead, it was found that infection contracted after exposure at home is associated with much higher mortality than infection contracted from someone outside the home.
The most likely interpretation of these observations, is that standard low-dose measles vaccine has a non-specific beneficial effect.
Contrary to current assumptions, children who survive the acute phase of measles infection may have a survival advantage compared with unimmunized, uninfected children.
In this perspective, the problem of high-titre immunization was apparently not that the vaccine was immunosuppressive, but that it may have lacked the non-specific beneficial impact of standard vaccine.
Should these observations be reproducable, they question the culture of'eradication'and have major implications for future immunization policies.
Mots-clés Pascal : Rougeole, Virose, Infection, Vaccination, Prévention, Enfant, Homme, Survie, Programme sanitaire, Efficacité
Mots-clés Pascal anglais : Measles, Viral disease, Infection, Vaccination, Prevention, Child, Human, Survival, Sanitary program, Efficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0497226
Code Inist : 002B05C02C. Création : 01/03/1996.