Performance of odds ratios obtained with a job-exposure matrix and individual exposure assessment with special reference to misclassification errors.
Objectives Individual assessment of exposure by experts and the use of a job-exposure matrix are the two main methods of evaluating past occupational exposures in community-based case-referent studies.
The objective of this study was to compare the performance of the estimations of the odds ratio in the two methods.
This paper focuses on job-exposure matrices whose entries consist of proportions of persons exposed.
Methods Simulations were used to compare the variances of the estimations of the odds ratios obtained with the two methods and to study the consequences with respect to bias and the precision of the odds ratios estimated for misclassifications of exposure produced by either the experts or the matrix.
Results When there was no misclassification, the results showed that the precision obtained with the job-exposure matrix was about three times less than that achieved by experts in a large range of practical situations.
Conclusions The evaluation of exposure with an unbiased job-exposure matrix in studies of the association between exposure and disease had a statistical power close to that expected in practice with a good expert in the large range of practical situations which were investigated.
Mots-clés Pascal : Méthode étude, Etude comparative, Exposition professionnelle, Homme, Analyse statistique, Expertise, Classification, Médecine travail, Odds ratio, Matrice emploi exposition, Histoire professionnelle
Mots-clés Pascal anglais : Investigation method, Comparative study, Occupational exposure, Human, Statistical analysis, Expertise, Classification, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0496909
Code Inist : 002B30B04. Création : 01/03/1996.