To evaluate the relations between environmental benzene concentrations and various biomarkers of exposure to benzene.
Methods-Analyses were carried out on environmental air, unmetabolised benzene in urine, trans, trans-muconic acid (ttMA), and three major phenolic metabolites of benzene ; catechol, hydroquinone, and phenol, in two field studies on 64 workers exposed to benzene concentrations from 0.12 to 68 ppm, the time weighted average (TWA).
Forty non-exposed subjects were also investigated.
Result-Among the five urinary biomarkers studied, ttMA correlated best with environmental benzene concentration (correlation coefficient, r=0.87).
The results from the present study also showed that both ttMA and hydroquinone were able to differentiate the background level found in subjects not occupationally exposed and those exposed to less than 1 ppm of benzene.
This suggests that these two biomarkers are useful indices for monitoring low concentrations of benzene.
Furthermore, these two metabolites are known to be involved in bone marrow leukaemogenesis, their applications in biological monitoring could thus be important in risk assessment.
Conclusion-The good correlations between ttMA, hydroquinone, and atmospheric benzene, even at concentrations of less than 1 ppm, suggest that they are sensitive and specific biomarkers for benzene exposure.
Mots-clés Pascal : Benzène, Solvant organique, Toxicité, Exposition professionnelle, Homme, Médecine travail, Marqueur biologique, Surveillance biologique, Métabolite, Urine, Liquide biologique, Pyrocatéchol, Hydroquinone, Phénol
Mots-clés Pascal anglais : Benzene, Organic solvent, Toxicity, Occupational exposure, Human, Occupational medicine, Biological marker, Biological monitoring, Metabolite, Urine, Biological fluid, Pyrocatechol, Hydroquinone, Phenol
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0496820
Code Inist : 002B03L04. Création : 01/03/1996.