Impaired colour discrimination among workers exposed to styrene : relevance of a urinary metabolite.
Objectives-To survey the loss of colour vision among Japanese workers who have been exposed to styrene concentrations currently considered low (about 20 ppm).
Also to assess the effects of styrene by examination of the nature of the relation between disorder of colour vision and age, alcohol consumption, and other variables.
Methods-Colour discrimination was examined in 64 male workers exposed to styrene (mean age ; 38.0, mean exposed years ; 7.0) and in 69 controls (mean age ; 38.0).
A standardised questionnaire was adopted to collect work history, occupational or non-occupational solvent exposure, alcohol consumption, and drug use.
Colour vision was evaluated by the Lanthony desaturated panel D-15 test.
The results of the test were expressed as the colour confusion index (CCI).
The mean atmospheric styrene concentration was about 20ppm.
The mean urinary concentration of mandelic acid was 0.22 g/l. There was a significant difference in CCI between exposed workers and age matched controls.
Colour vision of workers whose concentration of urinary mandelic acid was =0.42 g/l was significantly impaired when compared with workers whose concentration was (0.42g/l).
Conclusion-These findings suggest that exposure to moderate styrene concentrations can lead to impairment of colour vision, and that there is a significant correlation with the urinary metabolite of styrene.
Mots-clés Pascal : Styrène, Solvant organique, Toxicité, Exposition professionnelle, Homme, Médecine travail, Epidémiologie, Japon, Asie, Trouble vision, Vision couleur, Surveillance biologique, Urine, Métabolite
Mots-clés Pascal anglais : Styrene, Organic solvent, Toxicity, Occupational exposure, Human, Occupational medicine, Epidemiology, Japan, Asia, Vision disorder, Color vision, Biological monitoring, Urine, Metabolite
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0495900
Code Inist : 002B03L04. Création : 01/03/1996.