Objectives-To identify any differences in hepatic function between workers exposed to carbon tetrachloride and controls, and to identify the best variable with which to examine any effects.
Methods-In a cross sectional study of hepatic function in workers occupationally exposed to carbon tetrachloride, 135 exposed employees were compared with 276 non-exposed controls.
The exposed group was taken from three sites in the north west of England and the control group included non-exposed workers from one of these sites and another site located nearby.
Demographic and alcohol consumption data were collected from both groups by questionnaire.
Each member of the study group was allotted a notional estimated exposure to carbon tetrachloride, calculated from historic personal monitoring data and job category.
A fasting sample of blood was taken from all participants and analysed for a variety of biochemical and haematological variables.
The techniques of univariate and multivariate analysis of variance were used to investigate the effect on biochemical and haematological indices of a range of factors.
Conclusions-The most sensitive statistical methods have shown significant differences in the liver function variables measured between people exposed to carbon tetrachloride and the control group.
The interpretation of the data collected was that these differences may be due to exposure to carbon tetrachloride but this was not clearly shown.
Mots-clés Pascal : Méthane(tétrachloro), Solvant organique, Exposition professionnelle, Toxicité, Homme, Médecine travail, Fonction hépatique, Foie, Etude transversale, Epidémiologie, Royaume Uni, Europe, Surveillance biologique, Appareil digestif pathologie
Mots-clés Pascal anglais : Carbon tetrachloride, Organic solvent, Occupational exposure, Toxicity, Human, Occupational medicine, Liver function, Liver, Cross sectional study, Epidemiology, United Kingdom, Europe, Biological monitoring, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0495847
Code Inist : 002B03L04. Création : 01/03/1996.