An epidemiologic study was carried out to examine the possible role of bêta-agonists and other respiratory medications in the development of idiopathic dilated cardiomyopathy.
Associations with respiratory medications, bronchial asthma, emphysema, and chronic bronchitis were examined by comparing newly diagnosed cases (n=129) ascertained from five Washington, DC, area hospitals for the period 1990-1992 with neighborhood controls (n=258) identified by using a random digit dialing technique.
The cases and controls were matched on sex and 5-year age intervals and were compared in the analysis using conditional logistic regression methods.
A statistically significant association was observed between idiopathic dilated cardiomyopathy and history of emphysema or chronic bronchitis (adjusted odds ratio (OR)=4.4,95% confidence interval (01) 1.6-12.4).
The association with bronchial asthma was of borderline significance (adjusted OR=1.9,95% Cl 0.9-4.2).
Associations were also observed with use of oral bêta-agonists (adjusted OR=3.4,95% CI 1.1-11.0) and bêta-agonist inhalers or nebulization (adjusted OR=3.2,95% CI 1.4-7.1), as well as with use of oral corticosteroids, inhaled corticosteroids or cromolyn, and theophylline medications.
The results of this study suggest, but do not prove, that use of bêta-agonists has an etiologic role in idiopathic dilated cardiomyopathy.
Am J Epidemiol 1995 ; 142 : 395-403.
Mots-clés Pascal : Cardiomyopathie, Idiopathique, Epidémiologie, Toxicité, Agoniste, Récepteur bêta-adrénergique, Bronchodilatateur, Appareil respiratoire pathologie, Association, Homme, Chimiothérapie, Traitement, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Cardiopathie, Myocarde pathologie
Mots-clés Pascal anglais : Cardiomyopathy, Idiopathic, Epidemiology, Toxicity, Agonist, bêta-Adrenergic receptor, Bronchodilator, Respiratory disease, Association, Human, Chemotherapy, Treatment, United States, North America, America, Cardiovascular disease, Heart disease, Myocardial disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0487617
Code Inist : 002B02U07. Création : 01/03/1996.