To evaluate risk factors for coronary heart disease and factors which can influence the course of acute myocardial infarction in workers exposed to CS2 we performed a cross-sectional study of 247 workers in the viscose industry.
The control group of 222 men from the same plant was comparable for age, social status and physical work.
The CS2 exposure determined by personal air sampling ranged from<0.2 ppm to 65.7 ppm (median : 4.0 ppm) and the duration of exposure ranged from 4 to 220 (median : 66) months.
Using a multiple linear regression model we found neither higher blood pressure at rest or after exercise, nor hyperlipoproteinaemia in a higher degree, nor lower high-density lipoprotein (HDL) or lower apolipoprotein A-I levels, nor higher blood glucose values, nor indicators of direct cardiotoxic effects or signs of disturbances in blood coagulation in the exposed group in comparison to controls.
Regarding the influence of chronic exposure on the investigated parameters, we found an inverse correlation of the cumulative exposure with the HDL concentration.
The HDL levels correlated with the duration but not with the intensity of exposure.
At the current air-borne levels no significant differences were found between the exposed persons and the controls in the distribution frequency for blood pressure values, lipoproteins, blood glucose, blood coagulation and indicators of direct cardiotoxic effects.
Mots-clés Pascal : Carbone disulfure, Cellulose régénérée, Industrie textile, Toxicité, Exposition professionnelle, Homme, Appareil circulatoire pathologie, Cardiopathie coronaire, Cholestérol HDL, Apolipoprotéine, Travail posté, Médecine travail, Infarctus, Myocarde
Mots-clés Pascal anglais : Carbon disulfide, Cellulose hydrate, Textile industry, Toxicity, Occupational exposure, Human, Cardiovascular disease, Coronary heart disease, Cholesterol HDL, Apolipoproteins, Shift work, Occupational medicine, Infarct, Myocardium
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0487210
Code Inist : 002B03L06. Création : 01/03/1996.