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  1. The presence and subtype of Epstein-Barr virus in B and T cell lymphomas of the sino-nasal region from the Osaka and Okinawa disctricts of Japan.

    Article - En anglais

    BACKGROUND 

    Association between Epstein-Barr virus (EBV) and human malignancies, including sino-nasal lymphoma (SNL), has been suggested.

    EBV-associated malignancies have been reported to show distinct geographic distribution.

    EXPERIMENTAL DESIGN 

    In the present study, the presence of an EBV genome and its subtypes (type A and B) were examined in 52 cases of sino-nasal lymphomas of B and T cell type collected from two areas of Japan : Osaka, situated on the mainland, and Okinawa, islands situated in a southwest part of Japan with a subtropical climate.

    Our previous epidemiologic study showed that the frequency of nasal T cell lymphoma was 3.5 times higher in Okinawa than in Osaka.

    RESULTS 

    There were no prominent differences in age distribution or sex ratio between these two areas.

    All but one patient had type A EBV.

    The in situ hybridization confirmed the results of PCR as positive signals in the nucleus of proliferating cells.

    Latent membrane protein-1 was expressed in 13 of 22 cases (59%). CONCLUSIONS : These findings suggest that EBV, exclusively type A, might be a causative factor in sino-nasal lymphoma of not only T cell but also B cell type in Japan.

    Mots-clés Pascal : Lymphome non hodgkinien, Lymphocyte T, Lymphocyte B, Homme, Japon, Asie, Etude comparative, Epidémiologie, Sérotype, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Sinus face, Nez, Association, Virose, Infection, Hémopathie maligne, Lymphoprolifératif syndrome, Nez pathologie, Sinus face pathologie, ORL pathologie

    Mots-clés Pascal anglais : Non Hodgkin lymphoma, T-Lymphocyte, B-Lymphocyte, Human, Japan, Asia, Comparative study, Epidemiology, Serotype, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Paranasal sinus, Nose, Association, Viral disease, Infection, Malignant hemopathy, Lymphoproliferative syndrome, Nose disease, Paranasal sinus disease, ENT disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0485909

    Code Inist : 002B19B. Création : 01/03/1996.