To examine the relation between low serum total cholesterol concentrations and causes of mortality.
Design-Cohort study of men followed up for an average of 14.8 years.
Setting-One general practice in each of 24 British towns.
Subjects-7735 men aged 40-59 at screening selected at random from the 24 general practices.
During the mean follow up period of 14.8 years there were 1257 deaths from all causes, 640 cardiovascular deaths, 433 cancer deaths, and 184 deaths from other causes.
Low serum cholesterol concentrations (<4.8 mmol/l), present in 5% (n=410) of the men, were associated with the highest mortality from all causes, largely due to a significant increase in cancer deaths (age adjusted relative risk 1.6 (95% confidence interval 1.1 to 2.3) ;<4.8 v 4.8-5.9 mmol/l) and in other non-cardiovascular deaths (age adjusted relative risk 1.9 (1.1 to 3.1)). Low serum cholesterol concentration was associated with an increased prevalence of several diseases and indicators of ill health and with lifestyle characteristics such as smoking and heavy drinking.
Conclusion-The association between comparatively low serum total cholesterol concentrations and excess mortality seemed to be due to preclinical cancer and other non-cardiovascular diseases.
This suggests that public health programmes encouraging lower average concentrations of serum total cholesterol are unlikely to be associated with increased cancer or other non-cardiovascular mortality.
Mots-clés Pascal : Métabolisme pathologie, Tumeur maligne, Association, Epidémiologie, Mortalité, Homme, Adulte, Mâle, Cholestérol, Maladie, Grande Bretagne, Royaume Uni, Europe, Lipide, Hypocholestérolémie
Mots-clés Pascal anglais : Metabolic diseases, Malignant tumor, Association, Epidemiology, Mortality, Human, Adult, Male, Cholesterol, Disease, Great Britain, United Kingdom, Europe, Lipids, Hypocholesterolemia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0480779
Code Inist : 002B22A. Création : 01/03/1996.