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  1. Hormone replacement therapy : characteristics of users and non-users in a British general practice cohort identified through computerised prescribing records.

    Article - En anglais

    Study objective

    To assess the feasibility of recruiting a cohort of women, including long term users of postmenopausal hormone replacement therapy (HRT), through computerised general practice prescribing records, and to compare clinical and demographic characteristics of users and non-user controls.

    Design Cross sectional analysis of questionnaire data.


    Subjects were recruited through 17 general practices in the Oxfordshire, south west Thames, and north west Thames regions that contributed to the VAMP Research Database.


    Main results -

    Users of HRT were more likely to have undergone hysterectomy than controls.

    Most women with a history of hysterectomy used unopposed oestrogen, while those with intact uteri generally used a combination of oestrogen and a progestagen.

    Among women who had undergone hysterectomy, HRT users did not differ significantly from controls over a range of demographic and clinical characteristics but they were more likely to be past users of oral contraceptives.


    Electronic general practice prescribing records provide a feasible and efficient method for recruiting women to a cohort of HRT.

    Women who agreed to participate in this study were not representative of the general population, emphasising the importance of internal controls in such a study.

    Among participants, HRT users who had not undergone hysterectomy showed evidence of better health than non-users on some dimensions.

    Mots-clés Pascal : Hormone, Traitement substitutif, Chimiothérapie, Postménopause, Homme, Femelle, Utilisateur, Recrutement, Etude cohorte, Informatique, Dossier médical, Méthodologie, Royaume Uni, Europe

    Mots-clés Pascal anglais : Hormone, Replacement therapy, Chemotherapy, Postmenopause, Human, Female, User, Recruitment, Cohort study, Computer science, Medical record, Methodology, United Kingdom, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0479827

    Code Inist : 002B02O. Création : 01/03/1996.