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  1. Leukemia after irradiation for endometrial cancer in Ontario.

    Article - En anglais

    Background

    In human studies, the risk of leukemia after ionizing radiation has been found to be increased more often than for any other cancer.

    It is useful to study patients with cancer treated with radiation because exposure can be measured accurately, follow-up may be long, and often a comparable and sizable nonexposed group exists.

    Women with endometrial cancer represent an excellent population for study because they meet these Developed Leukemia After Endometrial Methods.

    A population-based matched case-control study, nested among all patients with endometrial cancer diagnosed in Ontario, was undertaken to describe the relationship between radiation therapy and leukemia risk.

    Among 13,843 subjects treated from 1964 to 1987 who survived at least 1 year, 47 confirmed cases of leukemia were identified.

    Four control subjects were matched to each patient based on age, calendar year of diagnosis, and length of survival free of a second neoplasm.

    Medical records were abstracted, and radiation dose administered to active bone marrow was determined by dosimetry.

    Results

    An elevated risk of all leukemias other than chronic lymphocytic leukemia was observed, but only within the first 10 years after endometrial cancer treatment (odds ratio 12.0 ; 90% confidence interval 2.8-52.1).

    Conclusions

    There is an increased risk of leukemia associated with radiation therapy for patients with endometrial cancer, but only within the first 10 years after treatment.

    Mots-clés Pascal : Tumeur maligne, Endomètre, Homme, Radiothérapie, Traitement, Complication, Leucémie, Second cancer, Epidémiologie, Incidence, Etude cohorte, Ontario, Canada, Amérique du Nord, Amérique, Appareil génital femelle pathologie, Utérus pathologie, Hémopathie maligne

    Mots-clés Pascal anglais : Malignant tumor, Endometrium, Human, Radiotherapy, Treatment, Complication, Leukemia, Second cancer, Epidemiology, Incidence, Cohort study, Ontario, Canada, North America, America, Female genital diseases, Uterine diseases, Malignant hemopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0479772

    Code Inist : 002B19B. Création : 01/03/1996.