Estimates of the incidence of significant gastrointestinal (GI) bleeding among patients with rheumatoid arthritis (RA) vary and population based estimates of this event have been unavailable.
We examine the incidence of this event in a well defined cohort of patients with RA.
The study cohort consisted of patients with RA incident in Rochester, MN, between 1950 and 1974 and reported by Linos, et al (Am J Epidemiol 1980 ; 111 : 87-98).
These patients were followed for up to 40.5 yrs, and retrospective analysis of hospitalization for GI bleeding was performed.
A total of 58 patients with RA were hospitalized for GI bleeding, including 46 patients who had a first episode of bleeding after the diagnosis of RA was made, for a first episode incidence rate of 0.52% per person-year of followup.
Overall survival among all patients with RA was slightly less than expected in the general population, while survival in patients hospitalized for GI bleeding was significantly lower than that of nonhospitalized patients.
In a nested case-control study, nonsteroidal antiinflammatory drug use was found to be a significant risk factor for hospitalization for GI bleeding.
Estimates of the overall incidence of hospitalization for GI bleeding in this population based cohort of patients with RA may be somewhat lower than some reported for referral populations, but an upward trend in recent years is noted.
Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Minnesota, Etats Unis, Amérique du Nord, Amérique, Hémorragie, Gastrointestinal, Association, Epidémiologie, Facteur risque, Etude cohorte, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Minnesota, United States, North America, America, Hemorrhage, Gastrointestinal, Association, Epidemiology, Risk factor, Cohort study, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Digestive diseases, Gastric disease, Intestinal disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0479650
Code Inist : 002B15D. Création : 01/03/1996.