Survival after curative resection of lymph node negative colorectal carcinoma : a prospective study of 910 patients.
Approximately half of all patients treated for colorectal carcinoma by bowel resection have neither lymph node metastases nor known residual tumor (clinicopathologic Stages A and B).
The aim of this study was to compare the survival of these patients with that of the general population and to explain any significant difference.
Prospectively collected data recorded for 910 patients from one institution during a period of 21.5 years were used in the analysis.
Patient follow-up ranged from 6 months to 21.5 years.
The « Survival » procedure, developed by the Finnish Cancer Registry, was used to compare the observed survival of patients with their expected survival, based on age-and sex-matched data from the population of New South Wales.
Survival analysis was performed by the Kaplan-Meier method.
Multivariate models were examined using Cox proportional hazards regression.
Males with tumor spread beyond the muscularis propria (Stage B) was the only group with significantly poorer survival than expected.
The reduced survival in this group was due to the effects of four clinical variables (cardiovascular complication, permanent stoma, urgent operation, respiratory complication) and one pathologic variable (direct spread involving a free serosal surface) acting independently.
The survival of patients with clinicopathologic Stages A or B tumors closely matched their expected survival as predicted from the general population.
Mots-clés Pascal : Epithélioma, Côlon, Rectum, Résection chirurgicale, Traitement, Stade précoce, Pronostic, Etude cohorte, Etude longitudinale, Epidémiologie, Appareil digestif pathologie, Intestin pathologie, Anorectale pathologie, Tumeur maligne, Chirurgie
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Surgical resection, Treatment, Early stage, Prognosis, Cohort study, Follow up study, Epidemiology, Digestive diseases, Intestinal disease, Anorectal disease, Malignant tumor, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0477560
Code Inist : 002B13B01. Création : 01/03/1996.