Reproductive-related factors play a major role in the aetiology of cancers of the breast, ovary and endometrium.
Pregnancy history influences the risk of each of these cancers, and oral contraceptive use modifies the risks of ovarian and endometrial cancers, although its effect on breast cancer risk is less certain.
We analysed recent time trends in the incidence and mortality of these cancers in England and Wales and assessed whether they can be explained by changes in fertility and oral contraceptive use.
During 1962-87, there were significant increases in the overall incidence of breast cancer (0.95% increase per annum) and ovarian cancer (0.76% per annum) but little increase in endometrial cancer (0.13% per annum).
At young ages incidence of each of the cancers has declined in recent years, whereas at older ages there have been substantial increases.
The fall in risk for women born after the 1920s was not accompanied by significant increases in their fertility, but coincided with the introduction and increase in use of oral contraceptives.
For ovarian and endometrial cancers this accords with strong evidence from person-based studies of the protective effect of oral contraceptives.
For breast cancer, the reasons for the recent decline are not clear.
It would accord with recent suggestions of a long-term protective effect of oral contraceptives, on which further studies are needed.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Ovaire, Endomètre, Incidence, Epidémiologie, Mortalité, Fertilité, Contraceptif, Voie orale, Angleterre, Grande Bretagne, Royaume Uni, Europe, Pays de Galles, Homme, Glande mammaire pathologie, Ovaire pathologie, Appareil génital femelle pathologie, Utérus pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Ovary, Endometrium, Incidence, Epidemiology, Mortality, Fertility, Contraceptive, Oral administration, England, Great Britain, United Kingdom, Europe, Wales, Human, Mammary gland diseases, Ovarian diseases, Female genital diseases, Uterine diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0475841
Code Inist : 002B20E02. Création : 01/03/1996.