This study examined the association between cigarette smoking status and the development of lung metastases in a group of 835 women diagnosed with primary malignant unilateral breast cancer.
Female patients with breast cancer diagnosed between 1982 and 1991 at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, who provided information on their cigarette smoking history at the time of their diagnosis were included.
The subsequent disease status of patients was monitored by the RPCI Tumor Registry.
The Cox regression model was used to estimate the relationship between smoking status and the development of lung metastases, adjusting for the patient's age, stage of disease at diagnosis, and body weight.
Of those patients who developed lung metastases, 8.7% were nonsmokers, 14.1% were former smokers, and 14.3% were current smokers.
This study found a significant association between cigarette smoking history and risk of lung metastases developing in women diagnosed with primary invasive unilateral breast cancer.
The risk of lung metastases developing increased as the number of cigarettes smoked in a lifetime increased.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Complication, Métastase, Poumon, Tabagisme, Facteur risque, Relation dose réponse, Epidémiologie, Homme, Femelle, Glande mammaire pathologie, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Complication, Metastasis, Lung, Tobacco smoking, Risk factor, Dose activity relation, Epidemiology, Human, Female, Mammary gland diseases, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0475501
Code Inist : 002B20E02. Création : 01/03/1996.