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  1. European randomized study of screening for prostate cancer : progress report of Antwerp and Rotterdam pilot studies.

    Article - En anglais

    Background

    The feasibility of screening and early detection of prostate cancer are controversial issues at this time.

    To conduct a randomized screening study with prostate cancer mortality as the major endpoint is one possible solution to the present controversy.

    Methods

    Eight pilot studies have been conducted in the Netherlands (Rotterdam) and Belgium (Antwerp) to evaluate the feasibility of a large scale European randomized study of screening for prostate cancer.

    Randomization and all other administrative steps necessary to conduct a large scale screening study were evaluated in the two centers.

    Participation rates were from 30% - 42%. Essential adjustments in pilot protocols were made during the study and led to significant changes.

    Results

    Administrative procedures necessary to run a large scale randomized study were successfully established at the two centers.

    The experience can be used to establish similar procedures in other European countries.

    Conclusions

    The pilot studies led to a common, agreed set of minimal requirements for participation in the European study.

    These features include randomization, PC mortality as major endpoint, age 55-70 years, biopsy policy, rescreening interval, treatment policies, and follow-up.

    A randomized screening study seems to be feasible in Europe.

    Cancer 1995 ; 76 : 129-34.

    Mots-clés Pascal : Tumeur maligne, Prostate, Homme, Diagnostic, Stade précoce, Etude multicentrique, Echelon international, Randomisation, Faisabilité, Méthodologie, Pays Bas, Europe, Belgique, Dépistage, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie

    Mots-clés Pascal anglais : Malignant tumor, Prostate, Human, Diagnosis, Early stage, Multicenter study, International scope, Randomization, Feasibility, Methodology, Netherlands, Europe, Belgium, Medical screening, Male genital diseases, Urinary system disease, Prostate disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0475489

    Code Inist : 002B14D02. Création : 01/03/1996.