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  1. An integrated framework to identify significant human exposures (SHELs).

    Article - En anglais

    Typically, health risk assessment methodologies have been designed to assess risks associated with exposure to individual chemicals through one specific medium, such as air, water, or food.

    This is partly because classical experimental methodology is used to study pure chemicals, and partly because a majority of early promulgated environmental laws regulated chemicals in a given matrix via a specific route.

    Often, however, exposures in the ambient environment are through multiple routes, multiple media and to multiple chemicals.

    Presented here is a multimedia framework that health risk assessors can use to identify significant human exposure levels (SHELs) on a site-specific basis.

    This framework is presented in the context of a decision tree that links health guidance values such as minimal risk levels (MRLs) with site-specific data, using a range of decision-support models.

    It includes a provision to estimate a level of concern by comparing the estimated total dose (exposures) with guidance values established by the Agency, by other federal organizations, and by basket-survey results.

    If a SHEL has been identified, a range of follow-up public health actions may be indicated.

    This framework serves to (1) integrate the overall health assessment process, (2) evaluate the need for public health interventions, (3) incorporate innovative decision-support methods/models, and (4) demonstrate utility of such methods in public health practice and the pursuit of the Agency's mission.

    Mots-clés Pascal : Composé chimique, Toxique, Polluant, Environnement, Mélange complexe, Toxicité, Homme, Législation, Etats Unis, Amérique du Nord, Amérique, Evaluation, Risque, Recommandation, Méthode étude, Organisme réglementation, Programme recherche

    Mots-clés Pascal anglais : Chemical compound, Poison, Pollutant, Environment, Multicomponent mixture, Toxicity, Human, Legislation, United States, North America, America, Evaluation, Risk, Recommendation, Investigation method, Regulatory institution, Research program

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0472974

    Code Inist : 002B03M01. Création : 01/03/1996.