The validity of the toxicity equivalency factors (TEFs) approach to predicting toxicity of mixtures was investigated on the basis of the public health risk assessment that had been posted for different groups of halogenated aromatic hydrocarbons.
First, the minimal risk levels (MRLs) were derived based on the databases available for chlorinated dibenzo-p-dioxins (ODs), chlorinated dibenzofurans (CDFs), and polychlorinated biphenyls (PCBs).
The MRL values were then converted to 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (TCDD) toxicity equivalents (TEQs) and compared with each other.
There was a good correlation between intermediate duration oral MRLs for TCDD and 2,3,4,7,8-pentaCDF when expressed in TEQs (7 pg/kg/day and 15 pg/kg/day).
In environmental exposure, the total toxicity of halogenated aromatic hydrocarbons is not necessarily the sum of the total individual congener toxicities because individual congeners compete for the same receptor ; therefore, nonadditive behavior may occur.
Mots-clés Pascal : Polluant, Environnement, Hydrocarbure halogéné, Prédiction, Toxicité, Homme, Dibenzofurane(polychloro), Dibenzo-p-dioxine(polychloro), Biphényle(polychloro), Evaluation, Risque, Méthode étude, Equivalent dose, Facteur équivalence toxique
Mots-clés Pascal anglais : Pollutant, Environment, Halocarbon, Prediction, Toxicity, Human, Polychlorobiphenyl, Evaluation, Risk, Investigation method, Dose equivalent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0472972
Code Inist : 002B03L06. Création : 01/03/1996.