To assess the incidence and progression of diabetic retinopathy and explore risk factors associated with them among non-insulin-dependent diabetes mellitus (NIDDM) patients.
A total of 471 NIDDM subjects aged =40 were recruited from four primary health care centres of northern Taiwan in 1986 and followed up for 4 years.
Their ocular fundi were clearly visible by ophthalmoscopy and the status of diabetic retinopathy could be graded.
A structured questionnaire interview was conducted to collect basic data.
Overnight fasting venous blood was collected every year to measure the levels of glucose, glycosylated haemoglobin (HbA1c), cholesterol and high density lipoprotein cholesterol.
Among the 344 subjects who had no retinopathy initially, 66 subjects developed retinopathy 4 years later giving a 4-year cumulative incidence of 19.2%. Of the 120 subjects initially with background or preproliferative retinopathy, evidence of deterioration developed in 36 subjects.
The cumulative incidence of progression was 30%. Seven subjects developed proliferative retinopathy giving a cumulative incidence of progression to proliferative retinopathy of 5.8%. The univariate analysis disclosed that the development of retinopathy was correlated with mean tasting blood glucose (MFBG) and HbA1c, diabetic duration, diabetic treatment and residential area.
Mots-clés Pascal : Rétinopathie, Complication, Diabète non insulinodépendant, Homme, Epidémiologie, Etude longitudinale, Facteur risque, Taiwan, Asie, Nord, Incidence, Oeil pathologie, Endocrinopathie
Mots-clés Pascal anglais : Retinopathy, Complication, Non insulin dependent diabetes, Human, Epidemiology, Follow up study, Risk factor, Taiwan, Asia, North, Incidence, Eye disease, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0472529
Code Inist : 002B21E01B. Création : 01/03/1996.