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  1. Human immunodeficiency virus seroprevalence in an occupational cohort in a South African community.

    Article - En anglais

    Background 

    In the early years of the worldwide pandemic, there were no reported cases of acquired immunodeficiency syndrome in Lesotho, a small, mountainous country in South Africa.

    The initiation of the Lesotho Highlands Water Project has resulted in the influx of a migrant workforce of predominantly single males into a relatively isolated, mountainous area where human immunodeficiency virus (HIV) was previously unknown.

    Objective 

    To ascertain the HIV seroprevalence among a cohort of laborers at the Katse Dam construction site in Bokong, Lesotho.

    Methods 

    During the 5-week study period in late 1992, construction workers (age range, 15 to 59 years) who were first-time clinic users for any chief complaint were randomly selected for serological study.

    Surveillance complied with the Lesotho National AIDS Control Programme guidelines, which required unlinked, anonymous testing.

    Serum samples were screened by an enzyme-linked immunosorbent assay ; the results were confirmed by the Western blot technique.

    Results 

    Unlinked, anonymous HIV testing of 486 persons revealed a seroprevalence of 5.3% (26/486 ; 95% confidence interval, 3.3% to 7.3%). These data contrasted with a 0.8% seroprevalence in a similar age group in nearby villages that surrounded the construction project.

    Conclusions 

    Lesotho, in the early phase of the HIV/acquired immunodeficiency syndrome epidemic in Africa in the 1980s, was seemingly protected by its relative isolation.

    Mots-clés Pascal : Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Séropositivité, Etude cohorte, République Sud Africaine, Afrique, Milieu professionnel, Homme, Epidémiologie

    Mots-clés Pascal anglais : Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Seropositivity, Cohort study, South Africa, Africa, Occupational environment, Human, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0470479

    Code Inist : 002B06D01. Création : 01/03/1996.