Three polymorphisms of the apoprotein B gene selected on the basis of previously published reports as likely to be the most informative, were investigated in a cross-cultural study in Europe.
Students from 14 universities, grouped for analyses into five regions, were recruited as cases (n=682) if they had a paternal history of premature myocardial infarction.
There were significant regional differences in allele frequencies of the XbaI and VNTR polymorphisms but not of the signal peptide.
There were no significant differences in allele frequencies between cases and controls.
Adjusted for age, gender and region, the lipoprotein concentrations differed significantly with genotype.
The XbaI polymorphism was associated with differences in plasma cholesterol (P=0.007), triglyceride (P=0.050), apo B (P=0.001) and LDL cholesterol (P=0.01).
An interaction between XbaI genotype and body mass index was observed on plasma triglyceride (P=0.015) and apo B (P=0.005) concentrations.
The signal peptide deletion allele was associated with increased plasma cholesterol (P=0.03), apo B (P=0.04) and LDL cholesterol (P=0.02).
We conclude that, although they are associated with significant differences in lipoprotein concentrations within-and between-populations, the apo B DNA polymorphisms studied are of less value as indicators of cardiovascular risk-factor status in the offspring of individuals affected by the disease.
Mots-clés Pascal : Athérosclérose, Apolipoprotéine B, DNA, Biologie moléculaire, Cardiopathie coronaire, Cholestérolémie, Epidémiologie, Facteur risque, Exploration, Déterminisme génétique, Homme, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Analyse biochimique
Mots-clés Pascal anglais : Atherosclerosis, Apolipoprotein B, DNA, Molecular biology, Coronary heart disease, Cholesterolemia, Epidemiology, Risk factor, Exploration, Genetic inheritance, Human, Europe, Cardiovascular disease, Vascular disease, Biochemical analysis
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0468122
Code Inist : 002B12B01. Création : 01/03/1996.