Because the incidence of childhood acute lymphatic leukemia peaks between 2 and 4 years of age, the risk factors may exert their influence during the prenatal and/or the neonatal periods.
A nationwide case-control study was carried out to identify maternal and perinatal risk factors for this disease.
The case-control study was nested in cohorts defined by all live births in Sweden recorded in the nationwide Medical Birth Register.
Risk of childhood lymphatic leukemia at all ages increased with Down's syndrome (OR=20.0 ; 95% CI=4.2-94.2), maternal renal disease (OR=4.4 ; 95% CI=1.6-12.1), use of supplementary oxygen (OR=23 ; 95% CI=1.5-3.6), postpartum asphyxia (OR=1.8 ; 95% CI=1.2-2.6), birth weight of more than 4500 g (OR=1.7 ; 95% CI=1.1-2.7), and hypertensive disease during pregnancy (OR=1.4 ; 95% CI=1.0-1.9).
Down's syndrome affected risk mostly in children younger than 5 years, whereas other factors affected those children 5 years old or older.
Being one of a multiple birth also increased risk among older children (OR=2.5 ; 95% CI=1.0-6.0).
Several maternal and perinatal risk factors were found to be associated with childhood lymphatic leukemia, but they showed age-specific differences.
We concluded that most risk factors for childhood lymphatic leukemia remain unidentified in very young children. [J Natl Cancer Inst 87 : 908-914,1995].
Mots-clés Pascal : Leucémie lymphoblastique, Facteur risque, Epidémiologie, Mongolisme, Trisomie, Aneuploïdie, Aberration chromosomique, Chromosome G21 anormal, Chromosome anormal, Rein pathologie, Mère, Poids naissance, Asphyxie, Postpartum, Hypertension artérielle, Suède, Europe, Enfant, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome, Appareil urinaire pathologie, Appareil respiratoire pathologie, Etude cas témoin
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Risk factor, Epidemiology, Down syndrome, Trisomy, Aneuploidy, Chromosomal aberration, Abnormal G21 chromosome, Abnormal chromosome, Renal disease, Mother, Birth weight, Asphyxia, Puerperium, Hypertension, Sweden, Europe, Child, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome, Urinary system disease, Respiratory disease, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0459647
Code Inist : 002B19B. Création : 01/03/1996.