Melatonin production is regulated by both catecholamines and sympathetic activity.
Urine levels of the major metabolite of melatonin, 6-sulfatoxymelatonin, correlate well with serum melatonin levels and have been used to evaluate sympathetic output.
We tested the hypothesis that urinary levels of 6-sulfatoxymelatonin would reflect the change in adrenergic activity on working days compared with nonworking days during pregnancy.
Twenty-three healthy pregnant women, employed in a variety of occupations, including physicians, nurses, secretaries, salespeople, and laboratory workers were recruited from the clinics of the University of North Carolina School of Medicine.
As expected, both epinephrine and norepinephrine levels were higher on workdays than nonworkdays, 93% greater (p<0.001) and 52% (p<0.001), respectively.
In this subset of women the 6-sulfatoxy-melatonin levels were 106% higher on workdays compared with nonworkdays (p<0.002).
Melatonin secretion reflected the differences in adrenergic activity between workdays and nonworkdays.
Because levels were fairly constant across gestation, 6-sulfatoxymelatonin may have potential as a biologic marker for some aspects of stress in pregnancy and may be useful for studies evaluating the relationship between work and pregnancy outcomes.
However, because of large interindividual variations, subjects will have to be compared against themselves.
Mots-clés Pascal : Mélatonine, Catécholamine, Gestation, Système sympathosurrénalien, Homme, Femelle, Stress, Activité professionnelle, Poste travail, Médecine travail, Exploration, Hormone épiphysaire, Hormone aminoacide dérivé, 6-Sulfatoxymélatonine
Mots-clés Pascal anglais : Melatonine, Catecholamine, Pregnancy, Sympathoadrenal system, Human, Female, Stress, Professional activity, Workplace layout, Occupational medicine, Exploration, Pineal hormone, Aminoacid derivative hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0456250
Code Inist : 002B20F01. Création : 01/03/1996.