Several studies have found a smaller effect of breast cancer screening on breast cancer mortality in women aged younger than 50 years compared with older women.
Various possible reasons have been suggested for this, but none firmly is established.
The Swedish Two-County Study is a randomized trial of breast cancer screening of women aged 40-74 years, comprising with 133,065 women with a 13-year follow-up of 2467 cancers.
The Breast Cancer Detection Demonstration Project (BCDDP) is a nonrandomized screening program in the United States, with a 14-year follow-up of 3778 cancers in women aged 40-74 years.
The Swedish results by age were updated.
Results indicated that the reduced effect on mortality for women aged 40-49 years was due to a differential effect of screening on the prognostic factors of tumor size, lymph node status, and histologic type.
These results suggest that much, although not all, of the smaller effect of screening on mortality in women aged 40-49 years is due to faster progression of a substantial proportion of tumors in this age group and the rapid increase in incidence during this decade of life.
It is concluded that the interval between screenings should be shortened to achieve a greater benefit in this age group.
It is estimated that a 19% reduction in mortality would result from an annual screening regime.
Cancer 1995 ; 75 : 2507-17.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Age, Diagnostic, Stade précoce, Dépistage, Homme, Femelle, Mammographie, Périodicité, Programme sanitaire, Résultat, Suède, Europe, Glande mammaire pathologie, Exploration radiologique
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Age, Diagnosis, Early stage, Medical screening, Human, Female, Mammography, Periodicity, Sanitary program, Result, Sweden, Europe, Mammary gland diseases, Radiologic investigation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0453852
Code Inist : 002B20E02. Création : 01/03/1996.