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  1. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure.

    Article - En anglais

    Epidemiologic studies of residential radon exposure are burdened by an inability to estimate exposure accurately, low total exposure, and subsequent small excess risks.

    As a result, the studies have been inconclusive to date.

    Estimates of the hazard posed by residential radon have been based on analyses of data on miners, with recent estimates based on a pooling of four occupational cohort studies of miners, including 360 lung cancer deaths.

    Purpose 

    To more fully describe the lung cancer risk in radon-exposed miners, we pooled original data from 11 studies of radon-exposed underground miners, conducted a comprehensive analysis, and developed models for estimating radon-associated lung cancer risk.

    Methods 

    We pooled original data from 11 cohort studies of radon-exposed underground miners, including 65 000 men and more than 2700 lung cancer deaths, and fit various relative risk (RR) regression models.

    Results 

    The RR relationship for cumulative radon progeny exposure was consistently linear in the range of miner exposures, suggesting that exposures at lower levels, such as in homes, would carry some risk.

    The exposure-response trend for never-smokers was threefold the trend for smokers, indicating a greater RR for exposure in never-smokers.

    Conclusions 

    In the miners, about 40% of all lung cancer deaths may be due to radon progeny exposure, 70% of lung cancer deaths in never-smokers, and 39% of lung cancer deaths in smokers.

    Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Facteur risque, Epidémiologie, Exposition professionnelle, Radon, Radioisotope, Mine, Pollution intérieur, Logement habitation, Etats Unis, Amérique du Nord, Amérique, Homme, Bronche pathologie, Poumon pathologie, Appareil respiratoire pathologie, Médecine travail

    Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Risk factor, Epidemiology, Occupational exposure, Radon, Radioisotope, Mine, Indoor pollution, Housing, United States, North America, America, Human, Bronchus disease, Lung disease, Respiratory disease, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0452441

    Code Inist : 002B11A. Création : 01/03/1996.