Epidemiologic studies have shown that the association of genital human papillomavirus (HPV) with cervical cancer is strong, independent of other risk factors, and consistent in several countries.
There are more than 20 different cancer-associated HPV types, but little is known about their geographic variation.
Our aim was to determine whether the association between HPV infection and cervical cancer is consistent worldwide and to investigate geographic variation in the distribution of HPV types.
More than 1000 specimens from sequential patients with invasive cervical cancer were collected and stored frozen at 32 hospitals in 22 countries.
Slides from all patients were submitted for central histologic review to confirm the diagnosis and to assess histologic characteristics.
HPV DNA was detected in 93% of the tumors, with no significant variation in HPV positivity among countries.
HPV 16 was present in 50% of the specimens, HPV 18 in 14%, HPV 45 in 8%, and HPV 31 in 5%. HPV 16 was the predominant type in all countries except Indonesia, where HPV 18 was more common.
Our results confirm the role of genital HPVs, which are transmitted sexually, as the central etiologic factor in cervical cancer worldwide.
They also suggest that most genital HPVs are associated with cancer, at least occasionally. [J Natl Cancer Inst 87 : 796-802,1995].
Mots-clés Pascal : Tumeur maligne, Col utérus, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Prévalence, Variation géographique, Epidémiologie, Homme, Col utérus pathologie, Appareil génital femelle pathologie
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Prevalence, Geographical variation, Epidemiology, Human, Uterine cervix diseases, Female genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0452438
Code Inist : 002B20C02. Création : 01/03/1996.