Objectives-To assess the effect of an occupational exposure to talc dust on respiratory health.
Methods-166 talc millers from a French factory underwent spirometry and filled in a standardised respiratory questionnaire during their annual medical visit in 1989.
A full sized chest radiograph taken in 1987 for the subjects hired before 1982 was also available, for the others a radiograph taken when hired was used.
Radiography was repeated in 1992 for all subjects still active at this date (n=139).
The occupational exposure to talc dust was characterised for each workplace with 1440 personal samples collected since 1986 and by semiquantitative estimates of the historical exposure.
The geometric mean (range) of estimated exposure was 1.87 (0.5 to 50) mg/m3 and the estimated cumulative exposure at the date of spirometry was>150 y mg/m3 for 41 subjects.
After adjustment for smoking in a linear model the standardised residual values of both forced vital capacity and forced expiratory volume in one second decreased significantly with increasing exposure.
The prevalence of dyspnoea also increased after adjustment for smoking categories and age in a logistic regression.
Conclusion-This study shows an effect of high levels of talc dust both on functional variables and on the prevalence of small radiological images, but provides no clear evidence about the possible effect of present levels of exposure.
Mots-clés Pascal : Talc, Poussière, Exposition professionnelle, Toxicité, Appareil respiratoire pathologie, Homme, France, Europe, Médecine travail
Mots-clés Pascal anglais : Talc, Dust, Occupational exposure, Toxicity, Respiratory disease, Human, France, Europe, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0451682
Code Inist : 002B03L03. Création : 01/03/1996.