To evaluate lead exposure among lead-acid battery workers in Korea, to evaluate in more detail the erythrocyte pyrimidine 5'-nucleotidase (P5N) test for lead exposure, and to evaluate the abnormal accumulation of erythrocyte pyrimidine nucleotides in the battery workers.
Methods Activity of PSN and other biological variables were examined in 66 exposed workers in a lead-acid battery factory and in 26 non-exposed workers in Korea.
At the factory the time-weighted average of 13 (72%) of 18 air samples for lead exceeded 0.05 (range 0.012-4.468) mg/m3.
Blood lead concentration (PbB) in 39 of the 66 exposed workers was above 40 mug/dl, and the mean (SD) PbB in the exposed group was 45.7 (15.7) mug/dl.
Compared with the non-exposed group, free erythrocyte protoporphyrin in the exposed group was significantly increased, whereas erythrocyte P5N activity and activity of erythrocyte delta-aminolevulnic acid dehydratase (ALAD) were significantly inhibited.
Erythrocyte PSN activity had valid correlation biologically with PbB and with other biological variables, such as ALAD activity.
In 28 exposed workers, the concentration of erythrocyte pyrimidine nucleotides (uridine 5'-diphosphate-glucose and cytidine 5'-triphosphate) correlated inversely with P5N activity and positively with PbB.
Conclusions-These findings show that the depression of erythrocyte PSN activity by lead exposure results in the accumulation of erythrocyte pyrimidine nucleotides.
Mots-clés Pascal : Plomb, Exposition professionnelle, Batterie, Industrie, Homme, Pyrimidine-5'-nucleotide nucleosidase, N-Glycosidases, Glycosidases, Hydrolases, Enzyme, Erythrocyte, Surveillance biologique, Teneur air ambiant, Analyse chimique, Lieu travail, Corée, Asie, Médecine travail, Métal lourd
Mots-clés Pascal anglais : Lead, Occupational exposure, Battery, Industry, Human, Pyrimidine-5'-nucleotide nucleosidase, N-Glycosidases, Glycosidases, Hydrolases, Enzyme, Red blood cell, Biological monitoring, Ambient air concentration, Chemical analysis, Work place, Korea, Asia, Occupational medicine, Heavy metal
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0451680
Code Inist : 002B03L05. Création : 01/03/1996.