Objectives-To determine (a) reproducibility with previous cross sectional findings, and (b) the predictive value of initial release of tumour necrosis factor-a (TNF-a) towards later progression of coalworkers'pneumoconiosis (CWP).
Method-Release of monocyte TNF-a after in vitro stimulation with coal mine dust, silica, and endotoxin was measured in 104 retired miners and was related to stage of CWP (chest radiograph) and cumulative exposure.
A subgroup of 46 miners was screened by high resolution computed tomography (HRCT).
Prospective analysis of TNF-a (40 out of 104 miners involved in the previous TNF-a study) was done by relating initial TNF-a to five year progression of CWP measured by comparison of paired chest radiographs.
As observed previously, dust stimulated release of TNF-a was increased in miners, especially in the early stages of pneumoconiosis.
Cumulative exposure was related to pneumoconiotic stage but not to release of TNF-a.
This excluded TNF-a as an exposure marker.
Initial concentrations (1987) of TNF-a were related to later progression of CWP.
Miners who showed abnormally high dust stimulated release of TNF-a had an increased risk of progression in CWP.
Conclusions-These results show (a) the significant involvement of TNF-a in pneumoconiosis in humans induced by coal dust and (b) that this routine test possibly constitutes a powerful tool to estimate individual prognosis of pneumoconiotic disease, even after the end of occupational exposure.
Mots-clés Pascal : Pneumoconiose, Exposition professionnelle, Mine charbon, Homme, Surveillance biologique, Marqueur biologique, Facteur nécrose tumorale alpha, Cytokine, Poussière, Pronostic, Evolution, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Pneumoconiosis, Occupational exposure, Coal mine, Human, Biological monitoring, Biological marker, Tumor necrosis factor alpha, Cytokine, Dust, Prognosis, Evolution, Occupational medicine, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0451675
Code Inist : 002B03L03. Création : 01/03/1996.