Application of biomarkers in population studies for respiratory non-malignant diseases.
Guiding principles for the use of biological markers in the assessment of human exposure to environmental factors. Workshop. European Centre for Environment and Health. Workshop. Cracow POL, 1993/09/13.
Though the use of biomarkers has been mainly suggested for cancer studies, the possibility of its use in non malignant disease is considered.
Markers of internal dose, markers of biologically effective dose and markers of early biologically effect have been typically used in basic research and, more recently, in epidemiology to characterize genotoxic carcinogenic agents.
These markers (e.g. adducts to DNA or proteins) may be used mainly in the presence of chronic exposure to toxic agents (e.g. benzene or benzopyrene), additional markers such as carboxyhemoglobin, expired air to measure various VOC and heavy metals in biological fluids are also considered in the paper.
Since airway obstructive disease (asthma, chronic bronchitis, emphysema) are the main disorders influenced by environmental factors (including air pollution), markers of individual susceptibility, such as atopy increased responsiveness of airways, initial level of lung function, must be considered for a more precise evaluation of the relationship between environmental exposure and health effects.
Currently, the application of the determination of markers of exposure in non malignant disorders is very limited.
Characterization of long term exposure may be performed in organ fluids (blood, urine, saliva) however it is important to recognize that concentration at that level may not reflect that observed in the target organ (e.g. lung).
Mots-clés Pascal : Marqueur biologique, Adduit moléculaire, DNA, Hémoglobine, Homme, Epidémiologie, Appareil respiratoire pathologie, Pollution air, Pollution intérieur
Mots-clés Pascal anglais : Biological marker, Molecular adduct, DNA, Hemoglobin, Human, Epidemiology, Respiratory disease, Air pollution, Indoor pollution
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0450097
Code Inist : 002B11D. Création : 01/03/1996.