Guiding principles for the use of biological markers in the assessment of human exposure to environmental factors. Workshop. European Centre for Environment and Health. Workshop. Cracow POL, 1993/09/13.
The measurement of levels of organic pollutants and/or their metabolites in body tissues or fluids are specific markers of internal dose and, provided that the pharmacokinetic properties of the compounds in question are known, these levels may also be used as predictors of effects.
Although historical data still remain to be very useful in environmental studies, more reliable exposure measures than combination of environmental levels and such estimators as residential history, job titles, life-style habits, individual perceptions, etc., are highly desirable.
This has been clearly demonstrated in studies with 2,3,7,8-tetrachlorndibenzo-p-dioxin (TCDD), where more recent measurements of serum concentrations in persons earlier classified as belonging to exposed groups have indicated that severe misclassifications may have occurred in previous epidemiological studies.
This also demonstrates that, in retrospective studies, levels of persistent organic compounds are useful as markers of exposure, as their tissue levels mainly reflect previous exposures.
However, most organic compounds are readily metabolized and excreted from the human body, and in many instances it will not be possible with current methodology and instrumentation to detect transient organic pollutants at low levels in the blood.
In most cases, the use of urine samples offers a better opportunity to provide samples containing detectable levels.
Mots-clés Pascal : Polluant, Environnement, Composé organique, Toxicité, Homme, Marqueur biologique, Liquide biologique, Matériel biologique, Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Dibenzofurane(polychloro), Dibenzo-p-dioxine(polychloro), Biphényle(polychloro), Ochratoxine, Mutagène, Epidémiologie, Recommandation, Composé aromatique polycyclique, Produit cuisson, Aliment
Mots-clés Pascal anglais : Pollutant, Environment, Organic compounds, Toxicity, Human, Biological marker, Biological fluid, Biological material, Polychlorobiphenyl, Ochratoxin, Mutagen, Epidemiology, Recommendation, Polycyclic aromatic compound, Bakery product, Food
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0450089
Code Inist : 002B03M01. Création : 01/03/1996.