A long-term follow up was begun in 1982 on offspring of mothers who acquired toxoplasmosis during gestation.
The 114 newborns were subdivided into 3 groups : (1) 26 born to mothers with certain infection ; (2) 51 born to mothers with probable infection, and (3) 37 born to mothers with doubtful infection.
There were five infections in the first group (19.2%), three in the second (5.8%) and none in the third.
For purposes of data elaboration we considered only the 77 offspring of mothers with certain or probable infection.
Of these, 2 infected cases out of 52 (3.8%) were born to mothers with infection in the first trimester of pregnancy, 4 out of 21 (19%) in the second trimester, and two out of four in the third.
There were a total of 8 congenital infections (10.4%). Specific IgM antibodies were revealed in five out of eight infected children (62.5%). Infection was symptomatic in two children (2.6% of newborns at risk, 25% of infected cases), both born to mothers with infection in the second trimester.
In the other six cases diagnosis was reached by evaluating trends in antibody levels.
Therapy with spiramycin should be started in all newborns at risk, while the use of sulphamides and pyrimethamine is justified only after the presence of infection is confirmed.
Conclusion Identification of susceptible women before or early in pregnancy would permit adoption of preventive measures aimed at reducing the frequency of congenital infection which is still high in our case series.
Mots-clés Pascal : Toxoplasmose, Protozoose, Parasitose, Infection, Congénital, Nouveau né, Homme, Epidémiologie, Italie, Europe, Maladie congénitale, Transmission mère enfant
Mots-clés Pascal anglais : Toxoplasmosis, Protozoal disease, Parasitosis, Infection, Congenital, Newborn, Human, Epidemiology, Italy, Europe, Congenital disease, Mother to child transmission
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0439300
Code Inist : 002B20G03. Création : 01/03/1996.