The case-crossover study design is a method to assess the effect of transient exposures on the risk of onset of acute events.
Control information for each case is based on his/her past exposure experience, and a self-matched analysis is conducted.
Empiric evaluation of five approaches to the analysis of case-crossover data from a study of heavy physical exertion and acute myocardial infarction onset is shown.
The data presented are from the Onset Study, a case-crossover study of the determinants of myocardial infarction onset conducted in 45 centers from August 1989 to October 1992.
In model 1, exactly one control period (matched on clock-time) was sampled per case.
In models 2-4, up to 25 control periods were sampled, and the effect of clock-time on the baseline hazard of infarction was modeled.
In model 5, a census of the person-time experienced by each subject over the year preceding the infarction was sampled.
The 95% confidence interval for model 1 was 2.7 times wider, and the relative efficiency, defined as v/vM, where vM represents the asymptotic variance estimate of the estimated log relative risk with M control periods sampled per case, was only about 14% of model 5. In models 2-4, the efficiency increased with the number of control periods, regardless of the modeling assumptions.
Even with many control periods sampled, models 2-4 achieved only half the efficiency of model 5. Am J Epidemiol 1995 ; 142 : 91-8.
Mots-clés Pascal : Epidémiologie, Méthodologie, Modèle, Infarctus, Myocarde, Homme, Exercice physique, Echantillonnage, Analyse statistique, Etude cas témoin, Cardiopathie coronaire, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Epidemiology, Methodology, Models, Infarct, Myocardium, Human, Physical exercise, Sampling, Statistical analysis, Case control study, Coronary heart disease, Cardiovascular disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0438180
Code Inist : 002B30A01A1. Création : 01/03/1996.