Safe biotechnology. VI : Safety assessment, in respect of human health, of microorganisms used in biotechnology.
The assessment of microorganisms in respect to human health is an important step for the introduction of new natural and genetically modified production strains to biotechnology.
This report outlines the potential hazards posed by industrial microorganisms, important considerations related to pathogenicity, such as routes and portals of entry into the human body, mechanisms of spread of biological material and a definition of pathogenicity.
Furthermore the most important steps in the assessment of pathogenicity of unknown strains are described.
A short overview on characterization and in vitro and in vivo tests is presented.
The hazard related to allergens and toxic metabolites is reviewed and the choice of methods and the handling of strains with unknown potential are discussed.
Mots-clés Pascal : Article synthèse, Microbiologie industrielle, Microorganisme, Analyse risque, Pouvoir pathogène, Allergène, Toxine, Exigence sécurité
Mots-clés Pascal anglais : Review, Industrial microbiology, Microorganism, Risk analysis, Pathogenicity, Allergen, Toxin, Safety requirement
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0434721
Code Inist : 002A31A. Création : 01/03/1996.