To develop a proper protocol for biological exposure monitoring of acetone, we evaluated whether exposure to acetone on the previous day affects the biological monitoring value at the end of a work day.
One hundred and ten male workers exposed to acetone in three acetate fiber manufacturing plants were monitored using a liquid passive sampler on two consecutive working days after 2 days without exposure.
Urine samples were collected at the start of the workshift and the end of the shift on both days for each subject.
For ten exposed workers urine samples were collected approximately every 2 h during and after the first working day until the following morning.
Acetone concentrations in urine at the start of the first working day were 1.3 ± 2.4 (range : ND-14.1) mg/l in nonexposed workers and 2.4 ± 5.6 (range : ND-40.3) mg/l in exposed workers.
The urinary acetone concentration at the beginning of the second working day indicated that urinary levels of acetone do not decline to background level by the following morning when exposure concentration exceeds 300 ppm.
However, linear regression analysis demonstrated that the relationship between environmental exposure level and urine level was similar on the 1st day and the 2nd day.
Thus, although urine acetone levels did not return completely to baseline after high exposures, under the present exposure levels the exposure on the previous day did not significantly affect urinary acetone at the end of the workshift of the next day.
Mots-clés Pascal : Acétone, Exposition professionnelle, Médecine travail, Surveillance biologique, Urine, Solvant organique
Mots-clés Pascal anglais : Acetone, Occupational exposure, Occupational medicine, Biological monitoring, Urine, Organic solvent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0425911
Code Inist : 002B03L04. Création : 01/03/1996.