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  1. Body fat and stroke : unmasking the hazards of overweight and obesity.

    Article - En anglais

    Study objective

    It has been frequently noted that overweight and obesity have a stronger relationship to hypertension and diabetes mellitus than to the risk of stroke.

    The reason for this observation has not been clear.

    This study aimed to examine the lifelong relation between body fat and stroke to shed light on why the public health risks of overweight and obesity have tended to be obscured in previous epidemiological studies.

    Design

    Case-control study.

    Setting

    Eleven general practices in west Birmingham.

    Participants

    Altogether 125 men and women who had just had their first stroke and were aged 35-74 years and 198 controls frequency matched for age and sex were recruited over 24 months during 1988-90.

    Main results

    Those in both the thinnest and fattest quartiles of subscapular skinfold thickness were at increased risk of stroke compared with those in the middle quartiles (age adjusted odds ratios 2.12 (95% confidence interval (CI) 1.2,3.9) and 2.08 (1.1,3.8) respectively).

    When lifelong maximum reported body mass index was assessed the hazards of obesity but not leanness were seen and multiple risk factor adjusted.

    Conclusions

    Potentially important risks of excessive body fat for stroke can be obscured by both a history of cigarette smoking and thinness associated with deteriorating health.

    The results seem to explain why excess body fat has previously been consistently related to hypertension and diabetes mellitus but less consistently to stroke.

    Mots-clés Pascal : Accident cérébrovasculaire, Epidémiologie, Homme, Obésité, Poids corporel, Royaume Uni, Europe, Etat nutritionnel, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Trouble nutrition

    Mots-clés Pascal anglais : Stroke, Epidemiology, Human, Obesity, Body weight, United Kingdom, Europe, Nutritional status, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Nutrition disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0424564

    Code Inist : 002B17C. Création : 01/03/1996.