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  1. Mumps outbreak in a highly vaccinated school population : evidence for large-scale vaccination failure.

    Article - En anglais


    To describe an outbreak and to identify risk factors for mumps occurring in a highly vaccinated high school population. (Note : Highly vaccinated means a population in which more than 95% have been vaccinated.) Design and Participants : Survey and cohort study of 307 (97%) of 318 students.

    Outcome Measures 

    Mumps was defined as an illness with 2 or more days of parotid swelling.

    Serologic confirmation of infection was obtained in eight cases, seven of which were evaluated for presence of IgM antibody using immunofluorescent antibodies.

    Vaccination records were verified for 297 (97%) students.


    The overall attack rate is the highest reported to date (and to our knowledge) for a population demonstrating virtually complete mumps vaccine coverage.

    Even verified documentation of vaccination may not be an accurate indicator of an individual's protection against mumps.

    Vaccination failure may play an important role in contemporary mumps outbreaks.

    We found no evidence to indicate that waning immunity (secondary vaccine failure) contributed significantly to this outbreak.

    A second dose of mumps vaccine, as recommended using measles-mumps-rubella vaccine, could potentially prevent similar outbreaks in secondary school populations in the future.

    Mots-clés Pascal : Oreillons, Virose, Infection, Adolescent, Homme, Epidémie, Epidémiologie, Milieu scolaire, Vaccination, Texas, Etats Unis, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Mumps, Viral disease, Infection, Adolescent, Human, Epidemic, Epidemiology, School environment, Vaccination, Texas, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0414187

    Code Inist : 002B05C02C. Création : 01/03/1996.