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  1. Bloodstream infections associated with a needleless intravenous infusion system in patients receiving home infusion therapy.

    Article - En anglais

    Objective

    - To determine risk factors for bloodstream infections (BSls) in an outbreak among patients receiving home intravenous infusion therapy.

    Design

    Case-control and retrospective cohort studies.

    Setting

    - Home health agency.

    Patients

    - Patients receiving home intravenous infusion therapy from Rhode Island Home Therapeutics (RIHT) from January through December 1993.

    Main Outcome Measure

    - Development of primary BSI.

    Methods

    - We compared patients with BSI (ie, case patients) with randomly selected noninfected RIHT patients receiving intravenous therapy, conducted a cohort study of all RIHT patients receiving intravenous therapy via a central venous catheter (CVC), and conducted a culture survey of injection cap luminal fluid.

    Results

    - Case patients were more likely than controls to have had therapy via a CVC (11/11 vs 14/32 ; odds ratio [OR] undefined ; P<. 001) or total parenteral nutrition and intralipid therapy (TPN/IL) (9/11 vs 3/32 ; OR, 43.5 ; 95% confidence interval [Cl], 4.9 to 510.0).

    Among RIHT patients with CVCs, risk factors for BSI were receipt of TPN/IL (9/35 vs 2/67 ; rate ratio [RR], 8.6 ; 95% Cl, 2.0 to 37.7) or use of a needleless infusion system.

    Only the combination of both exposures was significantly associated with development of a BSI (P<. 001).

    Conclusions

    - Our data suggest that a needleless device used for TPN/IL was associated with increased risk of BSI when injection caps were changed every 7 days.

    Mots-clés Pascal : Facteur risque, Infection, Iatrogène, Chimiothérapie, A domicile, Perfusion, Voie intraveineuse, Homme

    Mots-clés Pascal anglais : Risk factor, Infection, Iatrogenic, Chemotherapy, At home, Perfusion, Intravenous administration, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0411864

    Code Inist : 002B27B14B. Création : 01/03/1996.