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  1. Interaction between oncogene activation and tumor suppressor gene activation in the genesis of five human neoplasias. A mathematical study.

    Article - En anglais

    The purpose of this study is to elucidate the nature of the mathematical regularity between the incidence of two particular neoplasia in their risk variations in space using world statistics.

    Our investigation covered 5 cancers in the tumor spectrum, 47 cancer registration units in space, and 1978 to 1982 in time.

    More specifically, the emphasis of study was on investigating the relation between the type of data distribution and the fitness of a given cancer pair to a mathematical equilibrium model under the control of the law of mass action.

    The results obtained are as follows :

    1) A total of 7 tumor pairs investigated were divided into 3 elementary types according to their data distribution pattern - globular star cluster type, Galaxy-profile type, and open star cluster type. 2) Mathematically, the fitness of cancer pairs to the suggested equilibrium model decreased in the above order - a finding to indicate that a variety of interactions between centripetal force and centrifugal force are responsible for the production of the above data distribution types. 3) Evidence was presented to suggest that the activated oncogene system and the activated tumor suppressor gene system are the sources of the centripetal force and the centrifugal force, respectively, and that the equilibrium point of the former is very often different from the contra-equilibrium point of the latter in their locations.

    Mots-clés Pascal : Tumeur maligne, Homme, Epidémiologie, Carcinogenèse, Gène onc, Gène suppresseur tumeur, Activation, Equilibre, Interaction, Modèle mathématique, Etude théorique

    Mots-clés Pascal anglais : Malignant tumor, Human, Epidemiology, Carcinogenesis, Onc gene, Tumor suppressor gene, Activation, Equilibrium, Interaction, Mathematical model, Theoretical study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0408183

    Code Inist : 002B04B. Création : 01/03/1996.