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  1. Angiosarcoma in Japan : a review of 99 cases.

    Article - En anglais


    Angiosarcoma is rare, and information about its clinical features are limited.

    Therefore, a large scale study of angiosarcoma was performed in Japan.


    Through a nationwide Japanese study, 99 cases of angiosarcoma were collected and their clinicopathologic findings were summarized relative to predisposing risk factors.


    The patient age at diagnosis was 3-92 years, (mean, 62 years), with a two to one male to female ratio.

    The head and face were the most common primary site (29 cases) ; other sites were liver (17) ; trunk (13) :

    • The head and face were the most common primary site (29 cases) ;

    • other sites were liver (17) ;

    • pleural cavity (6), chest wall (2), abdominal wall (2), buttock (2), inguinal region (1) ;

    • heart (12) ;

    • and extremities (7).

    The proven predisposing risk factors included chronic pyothorax for angiosarcoma in the pleural cavity (six), thorotrast in the liver (five), radiotherapy to the abdominal wall and buttock (four), and chronic limb edema of the forearm (one).


    This study describes a different etiology in the development of angiosarcoma in patients from Japan compared with that of patients from Western countries, though the frequency of angiosarcoma among all soft-tissue sarcomas was similar in both areas.

    In Japan, chronic pyothorax, radiotherapy, and thorotrast proved to be distinctive causative factors of angiosarcoma.

    Cancer 1995 ; 75 : 989-96.

    Mots-clés Pascal : Angiosarcome, Homme, Mongoloïde, Epidémiologie, Site, Facteur risque, Histopathologie, Echelon national, Japon, Asie, Sarcome, Partie molle, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Angiosarcoma, Human, Mongoloid, Epidemiology, Site, Risk factor, Histopathology, National scope, Japan, Asia, Sarcoma, Soft tissue, Cardiovascular disease, Vascular disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0399281

    Code Inist : 002B04B. Création : 01/03/1996.