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  1. Increased risk of second malignant neoplasms outside radiation fields in patients with cervical carcinoma.

    Article, Communication - En anglais

    American Radium Society. Annual meeting. BMU, 1994/04/22.

    Background

    The relative risk of second primary cancers was evaluated in 125 women with International Federation of Gynecology and Obstetrics (FIGO) Stages I and II cervical carcinoma treated radically with radiation therapy between January 1980 and December 1990.

    Methods

    Medical records of patients were reviewed to evaluate the incidence of second malignant neoplasms.

    Only tumors histologically proven were scored.

    Results

    During the follow-up time (through December 1992), 10 women whose median age was 65.5 years at the time cervical cancer was diagnosed were found to have 11 second primary cancers.

    Nine of these cancers were metachronous with regard to cervical cancer and included breast (4), lung (2), myeloma (1), non-Hodgkin's lymphoma (1) and vulva (1).

    The metachronous tumors were diagnosed at a median age of 74 years and at median follow-up time of 34 months.

    Two of the cancers were synchronous with cervical cancer and included bladder (1) and thyroid (1).

    Conclusions

    An increased risk of second primary cancers developing was observed among 125 patients with FIGO Stages I and II cervical carcinoma, which may suggest an abnormal genetic background and/or a common etiology for the initial and second tumors.

    The increased risk of breast cancer occurring as a second primary is in contrast with previously published studies reporting a decreased risk of breast cancer in survivors of cervical-cancer (Cancer 1995 ; 75 : 2281-5).

    Mots-clés Pascal : Epithélioma, Col utérus, Radiothérapie, Homme, Second cancer, Complication, Incidence, Epidémiologie, Site, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Radiotherapy, Human, Second cancer, Complication, Incidence, Epidemiology, Site, Female genital diseases, Uterine cervix diseases, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0397736

    Code Inist : 002B20C02. Création : 01/03/1996.