Maternal reproductive history of fetal loss previously has been reported to be associated with an increased risk of leukemia in subsequent offspring.
Data from a Childrens Cancer Group (CCG) case-control study were analyzed to test the hypothesis that this association was dependent on the number of previous fetal losses and age at leukemia diagnosis.
A case-control study using a large Childrens Cancer Group database examined maternal history of fetal loss as a risk factor for childhood leukemia in subsequent offspring.
One thousand seven hundred fifty-three patients with childhood acute leukemia were compared with 839 community control subjects s and 2081 nonleukemia cancer control subjects.
A modest increase in risk was found to be associated with a history of fetal loss.
Stratification by age at diagnosis of leukemia showed that this association was significant only for those patients diagnosed before 4 years of age and most significant in those patients diagnosed before 2 years of age.
Childhood acute leukemia occurring at younger ages may be associated with an underlying genetic abnormality or chronic environmental exposure, which can be either lethal to the developing fetus or mutagenic and result in the development of acute leukemia.
Mots-clés Pascal : Leucémie myéloblastique, Leucémie lymphoblastique, Enfant, Homme, Epidémiologie, Facteur risque, Antécédent, Mère, Avortement, Spontané, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome, Gestation pathologie
Mots-clés Pascal anglais : Acute myelocytic leukemia, Acute lymphocytic leukemia, Child, Human, Epidemiology, Risk factor, Antecedent, Mother, Abortion, Spontaneous, Acute, Malignant hemopathy, Lymphoproliferative syndrome, Pregnancy disorders
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0396149
Code Inist : 002B19B. Création : 01/03/1996.