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  1. Colorectal cancer in patients with ulcerative colitis : a prospective cohort study in Italy.

    Article - En anglais


    The aim of this study was to assess the development of dysplasia or cancer in patients with ulcerative colitis and to determine the effectiveness of colonoscopy and biopsy follow-up in colon cancer surveillance.


    From 1980 to 1986,65 patients who had ulcerative colitis for 7 years or more participated in a surveillance program of colonoscopy and biopsy.

    This cohort was followed until December 1992.

    Forty-nine patients (75.4%) had extensive colitis and 16 (24.6%) left-sided colitis.

    The mean disease duration was 17.2 years.

    Three hundred four colonoscopies were performed.

    During each endoscopy, random biopsies were performed.


    Seven patients had definite dysplasia of the colorectal mucosa.

    Four of them had high grade lesions and underwent surgery.

    In all of these patients, colon cancer (3 Dukes'Stage A, 1 Dukes'Stage B) was found.

    No cancer was found in the other patients.

    Pedunculated adenomas were excised from 6 other patients during colonoscopy.


    Dysplasia, especially of high grade, is a marker of colon cancer risk in patients with longstanding ulcerative colitis.

    Intensive colonoscopy and biopsy surveillance can lead to the diagnosis of colon cancer at a potentially curable stage.

    In this series, older age appeared to be an additional risk factor.

    A careful selection of patients with ulcerative colitis seems mandatory to minimize the cost and optimize the benefit of colon cancer surveillance programs.

    Cancer 1995 ; 75 : 2045-50.

    Mots-clés Pascal : Rectocolite ulcérohémorragique, Homme, Tumeur maligne, Côlon, Rectum, Colonoscopie, Dysplasie, Epidémiologie, Facteur risque, Italie, Europe, Etude longitudinale, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Anorectale pathologie, Endoscopie

    Mots-clés Pascal anglais : Ulcerative colitis, Human, Malignant tumor, Colon, Rectum, Colonoscopy, Dysplasia, Epidemiology, Risk factor, Italy, Europe, Follow up study, Digestive diseases, Intestinal disease, Inflammatory disease, Anorectal disease, Endoscopy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0395860

    Code Inist : 002B13B01. Création : 01/03/1996.