Effect of different exposure compounds on urinary kinetics of aluminium and fluoride in industrially exposed workers.
To conduct a field study to obtain information on the urinary concentrations of aluminium (Al) and fluoride (F-) depending on the different compounds exposed to in the aluminium industry.
Methods---16 workers from one plant that produced aluminium fluoride (AlF3), and from two plants that produced aluminium electrolytically by two different processes participated in the study for one working week.
Pollutants were monitored by eight hour personal sampling every day, and urine samples were collected during the week.
Al and F-were analysed in both atmospheric and urine samples by atomic absorption spectrometry and an ion selective electrode.
The principal results show different characteristics of kinetic curves of Al and F-excretion in workers with different exposures.
Some characteristics of excretory peaks were linked to specific exposures-for instance, after exposure to AlF3 there was one delayed Al peak associated with one delayed F peak about eight hours after the end of the daily shift, and after mixed exposure to HF and AlF3, two F-peaks were noted, one fast peak at the end of the shift and another delayed peak at 10 hours synchronised with an Al peak.
Conclusion-These results reinforce the principle that, in biological monitoring, the sampling strategy and the choice of limit value should be dependent on kinetic data that take the exposure compound of the element in question into account.
Mots-clés Pascal : Aluminium, Exposition professionnelle, Toxicocinétique, Surveillance biologique, Urine, Fluorure, Homme, Excrétion, Médecine travail, France, Europe
Mots-clés Pascal anglais : Aluminium, Occupational exposure, Toxicokinetics, Biological monitoring, Urine, Fluorides, Human, Excretion, Occupational medicine, France, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0385730
Code Inist : 002B03L05. Création : 01/03/1996.