Objectives-Low exposures to volatile aromatic hydrocarbons and cytogenetic effects in peripheral white blood cells were determined in 25 healthy workers employed in different areas of a styrene production plant in the former German Democratic Republic.
The results were compared with 25 healthy unexposed controls (matched for age and sex) employed in the same company.
Methods-The concentrations of aromatic hydrocarbons determined from active air sampling in all areas of the factory which was only intermittently occupied for short periods.
Passive personal monitoring, biomonitoring of exhaled air and metabolites in urine samples collected before and after an eight hour working shift was used to assess individual exposure.
Questionnaires and examination of company records showed that the historical exposure was far higher than that measured.
Result-No genotoxic effects related to exposure were detected by DNA adducts or DNA single strand breaks and sister chromatid exchange.
The only effect related to exposure was an increase in kinetochore positive micronuclei in peripheral lymphocytes ; the frequency of total micronuclei in peripheral lymphocytes did not change.
Smoking was confirmed by measurement of plasma cotinine, and no confounding effect was found on any of the cytogenetic variables.
Conclusions-Low occupational exposure to styrene, benzene, and ethylbenzene did not induce alterations of genotoxicological variables except kinetochore positive micronuclei.
Mots-clés Pascal : Composé volatil, Composé aromatique polycyclique, Dose faible, Exposition professionnelle, Toxicité, DNA, Styrène, Industrie chimique, Allemagne(république démocratique), Allemagne, Europe, Médecine travail, Homme, Carcinogène, Mutagène
Mots-clés Pascal anglais : Volatile compound, Polycyclic aromatic compound, Low dose, Occupational exposure, Toxicity, DNA, Styrene, Chemical industry, East Germany, Germany, Europe, Occupational medicine, Human, Carcinogen, Mutagen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0384966
Code Inist : 002B03N. Création : 01/03/1996.