Objectives-To assess and quantify the occurrence of pleural malignant mesotheliomas in people who neither experienced occupational exposure to asbestos nor were married to workers exposed to asbestos in the workplace.
The study was conducted in the area of the local health authority of Casale Monferrato, in north western Italy, where a large factory that produced asbestos cement was active up to 1985.
No other major activities related to asbestos have ever been present in the area.
Methods-A retrospective survey covering the period 1980 to 1991 identified 126 incident pleural malignant mesotheliomas histologically diagnosed among residents in the local health authority.
Incidence excludes cases for which there was some suggestion of occupational or paraoccupational exposure to asbestos.
Incidence of histologically confirmed malignant mesothelioma among residents in the local health authority was 4.2 in men and 2.3 in women.
In both sexes, rates in 1985-9 were higher than in the previous quinquennium.
Corresponding estimates for 1990-1 suggest similar rates in men and women.
Conclusion-Rate ratios which are four to six times those measured by conventional Italian cancer registries can hardly be totally explained by bias produced by lack of recognition of occupational or paraoccupational exposure.
The problem of proving this type of negative data is common to other circumstances of alleged cancer clusters of environmental (non occupational) origin.
Mots-clés Pascal : Mésothéliome malin, Plèvre, Non professionnel, Amiante, Environnement, Polluant, Homme, Epidémiologie, Italie, Europe, Carcinogène, Toxicité, Fibre minérale, Tumeur maligne, Plèvre pathologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Malignant mesothelioma, Pleura, Non occupational, Asbestos, Environment, Pollutant, Human, Epidemiology, Italy, Europe, Carcinogen, Toxicity, Mineral fiber, Malignant tumor, Pleural disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0384950
Code Inist : 002B11A. Création : 01/03/1996.