HLA-DP and susceptibility to insulin-dependent diabetes mellitus in an ethnically mixed population. Associations with other HLA-Alleles.
It is known that certain combinations of alleles within the Human Leukocyte Antigen (HLA) Complex are associated with susceptibility or resistance to insulin-dependent diabetes mellitus (IDDM).
The association of DR and DQ with IDDM has been well documented.
Even though the association of specific DP alleles with some autoimmune diseases (i.e. juvenile rheumatoid arthritis URA] and celiac disease) has already been demonstrated, the role of HLA-DP genes in IDDM remains uncertain.
A previous study conducted on a group of diabetic Venezuelan families with IDDM proband demonstrated that the HLA-DRB1*04-DQA1*03-DQB1*0302 and DRB*03-DQA1*0501-DQB1*0201 combinations present a strong association with susceptibility to IDDM.
The availability of this population enabled us to assess further susceptibility associated with other HLA class II alleles.
We analysed HLA-DPA1 and DPB1 genes of 42 Venezuelan families with one IDDM proband and of 32 healthy families by oligotyping (PCR-SSO) using primers and probes from the XIth Histocompatibility Workshop.
These data and their comparison with HLA DR-DQ-DP haplotypes in more homogeneous ethnic groups support the existence of a weak association of IDDM with specific HLA DP alleles and indicate how the distribution of these DP alleles could differ depending on the ethnic groups studied.
Mots-clés Pascal : Diabète insulinodépendant, Homme, Déterminisme génétique, Système HLA, Locus HLA-DP, Antigène histocompatibilité classe II, Allèle, Venezuela, Amérique du Sud, Amérique, Etude familiale, Epidémiologie, Endocrinopathie, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Insulin dependent diabetes, Human, Genetic inheritance, HLA-System, HLA-DP-Locus, Class II histocompatibility antigen, Allele, Venezuela, South America, America, Family study, Epidemiology, Endocrinopathy, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0384385
Code Inist : 002B21E01A. Création : 01/03/1996.